COMPOSITION

Each 1 ml contains:
Florfenicol                                          300.0 mg
Flunixin meglumine                            27.4 mg

PROPERTIES

1-Therapeutic Group: Florfenicol :Antimicrobial , Flunixin Meglumine: anti-inflammatory drug

2-Therapeutic Class: Florfenicol :is a fluorinated analogue of chloramphenicol, Flunixin Meglumine is NSAIDs

3-Mode of Action:

1-Florfenicol is a synthetic broad spectrum antibiotic effective against most Gram-positive and Gram-negative bacteria involved in bovine respiratory disease which include Mannheimia haemolytica, Pasteurella multocida and Histophilus somni.Florfenicol acts by inhibiting bacterial protein synthesis at the ribosomal level and is bacteriostatic.

2-Flunixin meglumine is a non-steroidal anti- inflammatory drug with analgesic and antipyretic activity. Flunixin meglumine acts as a reversible non-selective inhibitor of cyclo-oxygenase (both COX 1 and COX 2 forms), Flunixin exerts its antipyretic effect by inhibiting prostaglandin E2 synthesis in the hypothalamus.

INDICATIONS

Curative treatment of respiratory infections (pneumonia) caused by Mannheimia haemolytica, Pasteurella multocida & Histophilus somni associated with pyrexia.

TARGET SPECIES

Beef and non-lactating dairy cattle only

WARNINGS & PRECAUTIONS

1-The product should be used in conjunction with susceptibility testing and take into account official and local antimicrobial policies.

2-Swab septum before removing each dose. Use a dry sterile needle and syringe.

3-Avoid use in dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.

4-Concurrent administration of potentially nephrotoxic drugs should be avoided.

5-Care should be taken to avoid accidental self- injection.

6-Wash hands after use.

7-Dose volume given at any one injection site should not exceed 10ml.

8-It is recommended to treat animals in the early stages of the disease and to evaluate the response to treatment 48 hours after injection.

9-flunixin, may mask a poor bacteriological response to florfenicol in the first 24 hours after injection.

10-Concomitant use of other NSAIDs or glucocorticosteroids with Intramix may result in gastrointestinal tract ulceration

CONTRA-INDICATIONS

1-Do not use in adult bulls intended for breeding purposes.

2-Do not use in animals suffering from hepatic and renal diseases.

3-Do not use if there is a risk of gastrointestinal bleeding or in cases where there is evidence of altered hemostasis.

4-Do not use in animals suffering from cardiac diseases.

5-Do not use in animals hypersensitive to the product.

6-Do not administer to animals less than 6 weeks of age.

7-Do not use in female dairy cattle 20 months of age or older. Use of florfenicol in this class of cattle may cause milk residues.

8-Do not use in calves to be processed for veal.

ADVERSE REACTIONS

Normal Dose :

Swelling at the site of injection.

Overdose :

Symptoms include: Decreased food consumption , decreased body weights, decreased water consumption, Tissue irritation increases with injection volume

DOSAGE AND ADMINISTRATION

1-Route of administration: Subcutaneous injection. The injection should only be given in the neck

 (2 ml /15 kg body weight) or (6 mL/100 lb)

WITHDRAWAL PERIODS

Meat and offal: 46 days.

Milk: In the absence of a withdrawal time in respect of milk, do not use in females producing milk for consumption, during lactation or drying off periods, nor in the 2 months preceding calving in animals to be used for producing milk for consumption in the future

STORAGE CONDITIONS

Store at temperature not exceeding 30°C and used after opening for 50 days at temperature not exceeding 30°C.

PACKAGING

Glass vials : 50 , 100 , 250 & 500 ml